NCT05384275

High-Flow Aerosol Generation Study

Aerosol Generation After Tracheal Extubation With High-flow Nasal Oxygen Therapy Compared With Standard Low-flow Oxygen Therapy: a Randomised Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 61 (actual)
• Sponsor: Papworth Hospital NHS Foundation Trust · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study will be measuring aerosol generated from the point of tracheal extubation after cardiac surgery in patients who then receive either high-flow nasal oxygen therapy (HFNT) or standard low-flow oxygen therapy, who have been consented to participate within another randomised controlled trial (The NOTACS Study, IRAS ID 278290). Aerosol generation will be compared at various sizes of particles \< 10 microns in size and sampled in different locations in the standardised patient care rooms in the ICU. The rate of change of aerosol generation, maximum aerosol generation and duration of aerosol production greater than background will be investigated. The aim is to compare high-flow and standard low-flow oxygen therapy to determine if there is a difference in aerosol generation between the therapies.

Conditions

• Oxygen Therapy; Heart Surgery

Interventions

Type	Name	Description
DEVICE	High Flow Nasal Therapy	High Flow Nasal Oxygen (Airvo2 Device)

Timeline

• Start date: 2021-05-17
• Primary completion: 2023-01-31
• Completion: 2023-01-31
• First posted: 2022-05-20
• Last updated: 2023-11-28

Locations

1 site across 1 country: United Kingdom