NCT05384158

Valuation in Depressed Mood, Anhedonia, and Anxiety

Evaluating Overlap and Distinctiveness in Neurocomputational Loss and Reward Elements of the RDoC Matrix

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 252 (estimated)
• Sponsor: Virginia Polytechnic Institute and State University · Academic / Other
• Sex: All
• Age: 25 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.

Detailed description

This study tests relationships among neural and behavioral valuation mechanisms, and how these mechanisms change (or not) over time, with task instructions, and following cognitive behavior therapy.

Conditions

• Neurobehavioral Components of Reward and Loss Valuation

Interventions

Type	Name	Description
BEHAVIORAL	cognitive behavioral therapy	cognitive behavioral therapy
BEHAVIORAL	valuation with instruction	repeat laboratory sessions of computerized learning game
BEHAVIORAL	valuation without instruction	repeat laboratory sessions of computerized learning game

Timeline

• Start date: 2021-08-01
• Primary completion: 2026-07-01
• Completion: 2026-07-01
• First posted: 2022-05-20
• Last updated: 2025-09-09

Locations

1 site across 1 country: United States