NCT05383833

Creatine to Augment Bioenergetics in Alzheimer's

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University of Kansas Medical Center · Academic / Other
• Sex: All
• Age: 60 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

By doing this study, researchers hope to see if creatine monohydrate is a helpful treatment for people with Alzheimer's disease.

Detailed description

Alzheimer's disease is a progressive brain disorder that causes memory and thinking problems. Current medications may temporarily help with symptoms but cannot stop the disease from getting worse. As such, new treatments that slow or stop the disease from progressing are needed. There is some evidence from animal studies that taking creatine monohydrate may improve thinking in Alzheimer's disease and be good for brain health. However, no studies have looked at creatine monohydrate supplementation in humans with Alzheimer's. Creatine monohydrate is a dietary supplement regulated by the FDA. This is a study that will test if taking creatine monohydrate may be a helpful treatment for people with Alzheimer's disease. In this study, investigators will will evaluate: 1. Whether persons with Alzheimer's disease are able to easily take creatine monohydrate for 8 weeks. 2. Whether creatine monohydrate affects thinking function in people with Alzheimer's Disease. 3. Whether creatine monohydrate affects certain biochemicals in the brain and body. 4. Whether creatine monohydrate improves muscle size and strength.

Conditions

• Alzheimer's Disease

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Creatine Monohydrate	Participants will take 20 grams of creatine monohydrate daily for 8 weeks.The 20 grams will be divided into two equal 10 gram doses that will be stirred into a beverage. One 10 gram dose will be taken in the morning and the other 10 gram dose in evening.

Timeline

• Start date: 2022-12-12
• Primary completion: 2024-05-14
• Completion: 2024-05-14
• First posted: 2022-05-20
• Last updated: 2024-08-14

Locations

1 site across 1 country: United States