NCT05383300

Intranasal Oxytocin in Antiosocial Personality Disorder and Psychopathy

Investigating the Effect of Oxytocin and the Neurochemistry of Antisocial Personality Disorder and Psychopathy Using Neuroimaging

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 72 (actual)
• Sponsor: King's College London · Academic / Other
• Sex: Male
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

A pharmacoimaging study of oxytcoin in antisocial personality disorder and psychopathy

Detailed description

Using a double-blinded, placebo controlled design, we explored similarities and differences in i) an important component of empathic processing (neural response to facial emotional expressions) and ii) decision-making in violent men with ASPD+/-Psychopathy, compared to healthy non-offenders (NO; n= 21 across studies), with placebo and after acute application of intranasal oxytocin, using functional Magnetic Resonance Imaging (fMRI).

Conditions

• Antisocial Personality Disorder

Interventions

Type	Name	Description
DRUG	Oxytocin nasal spray	Intranasal spray containing 40 IU of oxytocin
OTHER	Placebo spray	Application of inert placebo, identical in odor, color, and droplet size except for absence of oxytocin

Timeline

• Start date: 2017-05-01
• Primary completion: 2020-03-01
• Completion: 2021-12-01
• First posted: 2022-05-20
• Last updated: 2022-05-20

Locations

1 site across 1 country: United Kingdom