NCT05382598

Timing of Renal Replacement Therapy In Mechanically Ventilated Patients

Early Versus Late Renal Replacement Therapy In Mechanically Ventilated Patients With Acute Kidney Injury

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 94 (actual)
• Sponsor: Alexandria University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a randomized controlled study that will be conducted on acute kidney injury (AKI) patients, who are mechanically ventilated, to assess the impact of implementation of early renal replacement therapy (RRT) compared to late RRT on patients outcome.

Detailed description

The study subjects will be randomly divided into two groups (arms). The first one will be patients who will receive early renal replacement therapy (RRT) according to predefined criteria that will be illustrated later. The other group of patients will be those who receive late RRT according to the absolute indications of emergency hemodialysis i.e. severe hyperkalemia, life-threatening acidosis, uremic encephalopathy or pericarditis in addition to intractable pulmonary edema. Appropriate randomization technique will be applied. A computer-based program will be used to perform the randomization procedure.

Conditions

• Timing of RRT in Mechanically Ventilated Patients

Interventions

Type	Name	Description
PROCEDURE	Renal replacement therapy	Renal replacement therapy (RRT) will be initiated in the early group for patients who have stage 2 AKI according to KDIGO classification. The late group will have RRT when they develop any of the absolute indications for RRT

Timeline

• Start date: 2022-06-28
• Primary completion: 2023-11-20
• Completion: 2023-11-28
• First posted: 2022-05-19
• Last updated: 2023-12-04

Locations

1 site across 1 country: Egypt