NCT05380167

Efficacy Long-term Dietary Nitrate Consumption to Plasma Nitrite Conversion

Efficacy and Variability in Plasma Nitrite Levels During Long-term Supplementation With Nitrate Containing Beetroot Juice

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: Wake Forest University · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The objective of this study was to determine the chronic effects of beetroot juice supplementation on the acute (90-minute post nitrate consumption) efficacy of converting dietary nitrate to plasma nitrate and plasma nitrite in healthy middle-to-older aged adults. the investigators were also interested in determining the effect of this intervention on fasting levels of plasma nitrate and nitrite over time. Furthermore, the number of participants classified as "non-responders" was determined based on increases in plasma nitrite achieved using tolerable volumes of beetroot juice by other studies.

Conditions

• Cardiovascular Diseases in Old Age

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	BRJ Nitrate	Participants in this group drank daily for 12 weeks a 70 mL bottle of Beet It Sport drink with nitrate.
DIETARY_SUPPLEMENT	BRJ Placebo	Participants in this group drank daily for 12 weeks a 70 mL bottle of Beet It Sport drink without nitrate

Timeline

• Start date: 2017-09-01
• Primary completion: 2019-05-01
• Completion: 2019-05-01
• First posted: 2022-05-18
• Last updated: 2022-05-25

Locations

1 site across 1 country: United States