NCT05378984

Cocoa Intake and Muscle Pain Sensation

Cocoa Intake and Muscle Pain Sensation: an Experimental Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Karolinska Institutet · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This experimental randomized, double-blind, and controlled study included fifteen young, healthy, and pain-free men and 15 age-matched women. It lasted for three visits with at least one-week washout. Pain was experimentally induced, twice at each visit, with intramuscular injections of 0.2 mL hypertonic saline (5%), before and after intake of one of the different chocolate-types; white (30% cocoa-content), milk (34% cocoa-content), dark (70% cocoa-content). Pain duration, pain area, peak pain, and pressure pain threshold were assessed every fifth minute after each injection, between the time-points 5 to 30 min. Prior to inclusion, all participants underwent an examination in a dental chair. This included a clinical examination of the orofacial region according to the Diagnostic Criteria for temporomandibular disorders (DC/TMD) by a blinded examiner. Participants were also examined regarding their psychosocial status prior to inclusion, this included depression, somatization, anxiety, pain catastrophizing and stress.

Conditions

• Muscle Pain

Interventions

Type	Name	Description
OTHER	before - hypertonic saline 5%	pain was induced by intramuscular injections of hypertonic saline (5%)
OTHER	after - hypertonic saline 5%	pain was induced by intramuscular injections of hypertonic saline (5%)

Timeline

• Start date: 2020-03-01
• Primary completion: 2020-12-20
• Completion: 2020-12-20
• First posted: 2022-05-18
• Last updated: 2022-05-24

Locations

1 site across 1 country: Sweden