NCT05376046

Study of Erythrocyte Parameters and Hypercoagulability in Sickle Cell Disease (SCD-TGA)

Study of Erythrocyte Parameters and Hypercoagulability in Sickle Cell Disease

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: BILLOIR · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Sickle cell disease (SCD) is an inherited haemoglobinopathy disorder caused by mutations in HBB gene with amino-acid substitution on β globin chain. The consequence is synthesis of altered haemoglobin S (HbS) which polymerises in red blood cell (RBC) at deoxygenated state. SCD is associated with chronic haemolytic anaemia, vaso-occlusive crisis (VOC) leading to frequent hospitalisation. The aim of the study was to to investigate whether a combination of routine laboratory biomarkers of haemolysis could be used to predict VOC development in confirmed SCD patients.

Conditions

• Sickle Cell Disease
• Vaso-occlusive Crisis

Interventions

Type	Name	Description
BIOLOGICAL	Erythrocytic parameters and thrombin generation assay measurement	Erythrocytic parameters and thrombin generation assay measurement

Timeline

• Start date: 2018-09-01
• Primary completion: 2025-09-01
• Completion: 2026-09-01
• First posted: 2022-05-17
• Last updated: 2022-05-24

Locations

1 site across 1 country: France