NCT05375487

The Effect of Natural Carbonated Mineral Water Consumption on Gastrointestinal Transit and Gut Microbiota - A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Universidade Nova de Lisboa · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Gastrointestinal discomfort is a common condition associated with aging, low levels of physical activity, and reduced intake of fibre, water, and magnesium. Several studies have reported a positive association between the consumption of hyper-mineral water containing high levels of bicarbonate, calcium, or magnesium and improvements in gastrointestinal transit. There is evidence that magnesium and sulphate, individually, exert a laxative effect; however, the impact of other minerals remains limited. Different mechanisms have been described to explain how the gut microbiota influences gastrointestinal transit. It is important to understand the characteristics of the gut microbiota and to determine whether the intake of hyper-mineral water, a natural source of minerals, can positively modulate it. The aim of this randomized, placebo-controlled trial is to evaluate the effects of carbonated mineral water consumption on gastrointestinal transit and gut microbiota composition.

Conditions

• Gastrointestinal Discomfort

Interventions

Type	Name	Description
OTHER	Natural Carbonated Mineral Water	Participants consume 1000 mL per day of natural carbonated mineral water for 4 weeks, divided into four portions: before breakfast, 30 minutes before lunch, during the afternoon, and 30 minutes before dinner. Any additional water intake, if desired, is provided by the study investigators and consists exclusively of low-mineral water in both study arms. Participants record their total weekly water consumption using an electronic form.
OTHER	Low Mineral Water	Participants consume 1000 mL per day of low-mineral water for 4 weeks, divided into four portions: before breakfast, 30 minutes before lunch, during the afternoon, and 30 minutes before dinner. Any additional water intake, if desired, is provided by the study investigators and consists exclusively of low-mineral water in both study arms. Participants record their total weekly water consumption using an electronic form.

Timeline

• Start date: 2023-04-05
• Primary completion: 2023-10-25
• Completion: 2023-11-20
• First posted: 2022-05-16
• Last updated: 2026-02-17

Locations

1 site across 1 country: Portugal