NCT05375383

Microbial Colonization of Oral Probiotics

Assessment of Colonisation of Probiotic Bacterium Streptococcus Salivarius in the Oral Cavity

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: BLIS Technologies Limited · Industry
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to evaluate the colonization efficacy of probiotic lozenges and powders containing specific prebiotics in healthy adults

Detailed description

This is a double-blind, randomized controlled colonization pilot study with no cross over to evaluate the colonization efficacy of lozenges and powders containing two different commercially available probiotic bacteria (S. salivarius K12 ) or S. salivarius M18 with or without 2 different prebiotic sugars or their combinations. Participants will be randomly assigned to one of the 12 groups consuming probiotic lozenge or powder containing Streptococcus salivarius K12 or S. salivarius M18 with or without prebiotics (e.g. sugars that may promote probiotic activity) over a seven day period. Saliva samples will be collected at predetermined time points pre and post intervention. Colonisation efficacy will be determined by enumerating the probiotic in the saliva samples using standard microbiological techniques.

Conditions

• Microbial Colonization

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Streptococcus salivarius K12 lozenge	In this study, a lozenge will be evaluated for its potential of delivering probiotic Streptococcus salivarius K12 to the oral cavity.
DIETARY_SUPPLEMENT	Probiotic S. salivarius K12 lozenges containing prebiotic A	In this study, a lozenge containing a prebiotic will be evaluated for its potential of delivering probiotic Streptococcus salivarius K12 to the oral cavity.
DIETARY_SUPPLEMENT	Probiotic S. salivarius K12 lozenges containing prebiotic B	In this study, a lozenge containing a prebiotic will be evaluated for its potential of delivering probiotic Streptococcus salivarius K12 to the oral cavity.
DIETARY_SUPPLEMENT	Probiotic S. salivarius K12 lozenges containing prebiotics A and B	In this study, a lozenge containing two prebiotics will be evaluated for its potential of delivering probiotic Streptococcus salivarius K12 to the oral cavity.
DIETARY_SUPPLEMENT	Probiotic S. salivarius K12 powder	In this study, a powder will be evaluated for its potential of delivering probiotic Streptococcus salivarius K12 to the oral cavity
DIETARY_SUPPLEMENT	Probiotic S. salivarius K12 powder containing prebiotic A	In this study, a powder containing a prebiotic will be evaluated for its potential of delivering probiotic Streptococcus salivarius K12 to the oral cavity
DIETARY_SUPPLEMENT	Probiotic S. salivarius K12 powder containing prebiotic B	In this study, a powder containing a prebiotic will be evaluated for its potential of delivering probiotic Streptococcus salivarius K12 to the oral cavity
DIETARY_SUPPLEMENT	Probiotic S. salivarius K12 powder containing prebiotics A and B	In this study, a powder containing two prebiotics will be evaluated for its potential of delivering probiotic Streptococcus salivarius K12 to the oral cavity
DIETARY_SUPPLEMENT	Probiotic S. salivarius M18 lozenges	In this study, a lozenge containing will be evaluated for its potential of delivering probiotic Streptococcus salivarius M18 to the oral cavity.
DIETARY_SUPPLEMENT	Probiotic S. salivarius M18 lozenges containing prebiotic A	In this study, a lozenge containing a prebiotic will be evaluated for its potential of delivering probiotic Streptococcus salivarius M18 to the oral cavity.
DIETARY_SUPPLEMENT	Probiotic S. salivarius M18 lozenges containing prebiotic B	In this study, a lozenge containing a prebiotic will be evaluated for its potential of delivering probiotic Streptococcus salivarius M18 to the oral cavity.
DIETARY_SUPPLEMENT	Probiotic S. salivarius M18 + lozenges containing prebiotic A and B	In this study, a lozenge containing two prebiotics will be evaluated for its potential of delivering probiotic Streptococcus salivarius M18 to the oral cavity.

Timeline

• Start date: 2022-06-15
• Primary completion: 2022-08-31
• Completion: 2022-09-15
• First posted: 2022-05-16
• Last updated: 2022-05-16

Locations

1 site across 1 country: New Zealand