NCT05374720

Analysis of the Molecular Composition of Tubal Cilia in Patients With or Without Ectopic Pregnancy

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Centre Hospitalier Intercommunal Creteil · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Primary Ciliary Dyskinesia associated with abnormalities of lateralization of organs (with existence of a situs inversus in 50% of cases) and secondary fertility disorders related in humans to abnormalities of mobility of sperm but very little data on the structure and function of tubal cilia in women

Detailed description

Primary Ciliary Dyskinesia (DCP) is a rare genetic disease (1 in 15,000 individuals at birth), which manifests itself in chronic respiratory infections (bronchopneumopathies and rhinosinusitis type) associated with abnormalities of lateralization of organs (with existence of a situs inversus in 50% of cases) and secondary fertility disorders related in humans to abnormalities of sperm mobility. However, there is very little data in the literature on the structure and function of tubal cilia in women with DCP. Before considering a study of tubal cilia in patients with DCP, it seems necessary to specify in DCP patients or not DCP, the molecular and morphological composition of tubal cilia and to look for ciliary abnormalities in case of GEU

Conditions

• Salpingectomy
• Hysterectomy
• Primary Ciliary Dyskinesia
• Ectopic Pregnancy

Interventions

Type	Name	Description
PROCEDURE	salpingectomy	Removal of one of the fallopian tubes.
PROCEDURE	hysterectomy	remove the uterus, whole or only part. It may also involve the removal of the cervix, ovaries, fallopian tubes and other surrounding structures.

Timeline

• Start date: 2022-10-01
• Primary completion: 2024-03-31
• Completion: 2024-12-31
• First posted: 2022-05-16
• Last updated: 2023-06-18

Locations

1 site across 1 country: France