NCT05373732

Stress Reduction in the Prevention of Left Ventricular Hypertrophy

Stress Reduction in the Prevention of Left Ventricular Hypertrophy: A Randomized Controlled Trial of Transcendental Meditation and Health Education in Hypertensive African Americans

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 171 (actual)
• Sponsor: Maharishi International University · Academic / Other
• Sex: All
• Age: 20 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This study evaluated the effect of stress reduction by Transcendental Meditation (TM) on left ventricular mass compared to a health education control group in pre-hypertensive or hypertensive African-American adults over a six-month intervention period.

Detailed description

Left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular disease (CVD). African Americans have higher rates of LVH and CVD than whites. Substantial evidence indicates that psychological stress contributes to LVH. This randomized controlled trial evaluated the effect of stress reduction with the Transcendental Meditation (TM) technique on left ventricular mass (LVM) in hypertensive African-Americans. Hypertensive African American men and women were tested at baseline for left ventricular mass index (LVMI) by M-mode echocardiography, blood pressure, lifestyle and behavioral factors. Subjects were randomly assigned to either TM or health education (HE) control. After six months intervention, 86 subjects were posttested on all outcomes. Data were analyzed for between-group and within-group differences.

Conditions

• Left Ventricular Hypertrophy
• High Blood Pressure

Interventions

Type	Name	Description
BEHAVIORAL	meditation	meditation practice 20 minutes twice a day at home and attending classes at the clinic.
BEHAVIORAL	Health education control	didactic based classes in CVD risk factor reduction and prevention

Timeline

• Start date: 1996-04-01
• Primary completion: 1998-10-01
• Completion: 1998-12-01
• First posted: 2022-05-13
• Last updated: 2022-05-13