NCT05372874

Treatment of Hepatitis c by Using Direct-acting Antiviral

Evaluation of the Effect of Direct-Acting Antiviral Agents on Melatonin Level in Chronic Hepatitis C Patients in Egypt.

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Tanta University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: —

Summary

Patients with hepatitis c showed increased level of oxidative stress. Increased level of serum lipid peroxidation leads to the production of toxic mediators as malondialdehyde (MDA) which lead to disease progression. Chronic stress shunt tryptophan which is essential amino acid toward kynurenic pathway leading to lower level of serotonin and melatonin level. Currently, direct-acting antivirals (DAAs) show well-established efficacy against hepatitis C virus (HCV).

Conditions

• Hepatitis C

Interventions

Type	Name	Description
DRUG	Direct Acting Antivirals	hepatitis C patients will be treated by direct acting antiviral drugs (DAAs)for 12 weeks.

Timeline

• Start date: 2022-05-06
• Primary completion: 2022-07-12
• Completion: 2022-07-30
• First posted: 2022-05-13
• Last updated: 2022-05-13

Regulatory

• FDA-regulated drug study