NCT05372510

Feasibility of Identifying, Enrolling and Following Acute and Early HIV-1 Infected Individuals.

A Pilot Study to Evaluate the Feasibility of Identifying, Enrolling and Following Acute and Early HIV-1 Infected Individuals.

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: MRC/UVRI and LSHTM Uganda Research Unit · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

It is only between peak viremia and viral setpoint in natural acute HIV-1 infection that the immune response overwhelms viral replication resulting in a plasma viral load decline. The aim will be to characterize these immune responses, how they develop and their progeny. This will require the need to identify HIV-1 infected individuals before peak viremia and follow them to post viral setpoint. This protocol describes a pilot study to evaluate the feasibility of identifying, enrolling and following acute and early HIV-1 infected individuals from voluntary counselling and testing centres in Masaka, Bukomansimbi, Kalungu, Lwengo, Sembababule and Lyantonde districts.

Conditions

• Acute Human Immunodeficiency Virus Type I Infection

Timeline

• Start date: 2021-02-17
• Primary completion: 2022-12-31
• Completion: 2022-12-31
• First posted: 2022-05-12
• Last updated: 2022-05-12

Locations

1 site across 1 country: Uganda