NCT05368532

Excitability Protocol: Voltage-gated Ion Channels

Novel Excitability Protocol to Identify Alteration of Voltage-gated Ion Channels

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Aalborg University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The purpose of subproject 1 is to evaluate the accuracy of a nerve excitability protocol in healthy subjects before testing the protocol in diabetic neuropathy patients. The nerve excitability protocol has been derived by computational modeling to identify abnormalities of three subtypes of ion voltage-gated channels. These three ion channels are all altered in animal models of diabetic neuropathy and, therefore, are likely candidates for generating the altered excitability in diabetic neuropathy patients. The hypothesis for subproject 1 is that due to the unique dynamics of each subtype of voltage-gated ion channels, it is possible to identify abnormal voltage-gated ion channel alterations by altering the shape of the electrical stimulation.

Conditions

• Pain

Interventions

Type	Name	Description
OTHER	Temperature	The temperature will be reduced for approximately one hour.

Timeline

• Start date: 2022-07-31
• Primary completion: 2023-12-01
• Completion: 2024-03-01
• First posted: 2022-05-10
• Last updated: 2023-08-02

Locations

1 site across 1 country: Denmark