NCT05368376

Is Labetalol More Effective Than Metoprolol for Controlled Hypotensive Anesthesia During Endoscopic Nasal Surgeries?

Is Labetalol More Effective Than Metoprolol for Controlled Hypotensive Anesthesia During Endoscopic Nasal Surgeries? A Randomized Clinical Trial.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Damanhour Teaching Hospital · Other Government
• Sex: All
• Age: 21 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Background: Mucosal bleeding is the most frequent complication with endoscopic nasal surgeries, as it interferes with the optimal visualization of the intranasal anatomy, leading to increased complications, operation duration, and blood loss. There are several pharmacological techniques for the appropriate control of intraoperative bleeding. Objectives: To compare the safety and efficacy of oral labetalol versus oral metoprolol as a premedication for controlled hypotensive anesthesia during endoscopic nasal surgeries. Patients and Methods: This is a randomized, double-blind, phase four, comparative clinical trial; carried out on 60 patients, who were candidates for endoscopic nasal surgeries under general anesthesia at our hospital. Patients were randomly allocated into two equal groups; group L, received oral labetalol, and group M, received oral metoprolol.

Conditions

• Hypotension Drug-Induced

Interventions

Type	Name	Description
DRUG	Labetalol Hydrochloride Oral Tablet	Labetalol 200 mg
DRUG	Metoprolol Tartrate Oral Tablet	Metoprolol 100 mg

Timeline

• Start date: 2021-04-01
• Primary completion: 2022-10-01
• Completion: 2022-10-15
• First posted: 2022-05-10
• Last updated: 2023-09-28

Locations

1 site across 1 country: Egypt