NCT05367336

Platelet Reactivity With Fentanyl, Morphine, or no Narcotic

A Comparison of PLAtelet Response to Aspirin Between Emergency Department Patients With Chest Pain Receiving Fentanyl or Morphine (PLAAFM)

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: Corewell Health South · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The goal is to determine whether fentanyl and morphine have similar effects in reducing aspirin's effect upon platelets in emergency department patients with chest discomfort. Morphine has been shown to worsen outcomes in heart attack patients due to reduction of oral anti-platelet agent effectiveness and so many providers have switches to using fentanyl. However, it is largely unknown whether fentanyl has similar effects.

Detailed description

Patients presenting to the emergency department with chest discomfort who are being administered aspirin will be offered enrollment in this study. At the time of their zero and two hour troponin we will also draw platelet aggregration studies to determine the effects of aspirin upon platelets. Narcotic medicines slow the absorption of aspirin. Morphine has therefore been shown to decrease the effectiveness of aspirin. Many providers therefore use fentanyl instead, however little is known about the effects of fentanyl upon aspirin. We will therefore compare the platelet reactivity of patients receiving morphine, fentanyl, or no narcotics

Conditions

• Fentanyl
• Platelet Reactivity

Interventions

Type	Name	Description
DRUG	Morphine	second group will be receiving morphine
DRUG	Fentanyl	third group receiving fentanyl

Timeline

• Start date: 2022-08-31
• Primary completion: 2025-02-18
• Completion: 2025-02-18
• First posted: 2022-05-10
• Last updated: 2025-05-21
• Results posted: 2025-04-25

Locations

1 site across 1 country: United States