NCT05365334

Skeletal Muscle and Adipose Tissue Responses After Acute Exercise: Comparing Effects of Three Different Intensities

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (actual)
• Sponsor: University of Michigan · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The study will assess the exercise-induced changes in chromatin accessibility and gene expression in a cell type-specific manner in skeletal muscle from healthy adults in response to exercise at three different intensities - 1) low-intensity continuous exercise, 2) moderate-intensity continuous exercise, and 3) high-intensity interval exercise.

Conditions

• Cellular Responses Within Skeletal Muscle in Response to Exercise of Different Intensities
• Relationship Between the Cellular Responses in Skeletal Muscle and the Changes in the Metabolomic Profile
• Changes Within Adipose Tissue in Response to Exercise at the Three Different Intensities

Interventions

Type	Name	Description
BEHAVIORAL	Low intensity exercise session	subjects will exercise at 30% maximal oxygen consumption (VO2max) for 45-60 minutes
BEHAVIORAL	Moderate intensity exercise session	subjects will exercise at 65% maximal oxygen consumption (VO2max) for 30-45 minutes
BEHAVIORAL	High intensity exercise session	subjects will completed 10x1minute exercise intervals at maximal oxygen consumption (VO2max) with 1 minute active recovery between

Timeline

• Start date: 2021-12-13
• Primary completion: 2023-06-23
• Completion: 2023-06-23
• First posted: 2022-05-09
• Last updated: 2024-07-26

Locations

1 site across 1 country: United States