NCT05362422

PAS for Post-SCI Neuropathic Pain

Paired Associative Stimulation for Post- Spinal Cord Injury Neuropathic Pain

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 5 (actual)
• Sponsor: Helsinki University Central Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The investigators have shown in incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles. In this study, the investigators will administer long-term paired associative stimulation to patients with incomplete cervical level SCI and SCI- associated neuropathic pain, and investigate its effectiveness for neuropathic pain treatment.

Conditions

• Spinal Cord Injury Cervical
• Neuropathic Pain

Interventions

Type	Name	Description
DEVICE	long-term paired associative stimulation	Paired associative stimulation (PAS) administered 3-5 times per week for 4 weeks to upper limbs. PAS comprises transcranial magnetic stimulation (eXimia magnetic stimulator, Nexstim Ltd, Helsinki, Finland) and peripheral nerve stimulation (given with Dantec Keypoint® electroneuromyography device (Natus Medical Incorporated, Pleasanton, CA, USA)).
DEVICE	sham long-term paired associative stimulation	Sham transcranial magnetic stimulation and sham peripheral nerve stimulation.

Timeline

• Start date: 2022-04-22
• Primary completion: 2023-05-22
• Completion: 2023-09-22
• First posted: 2022-05-05
• Last updated: 2023-09-25

Locations

1 site across 1 country: Finland