NCT05360342

Incorporation of Vitamin K Into Uremic Lipoproteins

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: RWTH Aachen University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Chronic kidney disease (CKD) patients have an increased cardiovascular risk with corresponding cardiovascular calcifications. CKD patients exhibit a functional vitamin K deficiency. Calcification can be prevented by vitamin K intake. The aim of this study is to investigate the cause for the vitamin K deficiency beyond a diminished dietary vitamin K uptake.

Detailed description

This study is a monocentric, 1-armed interventional trial. Participants will be recruited at the University Hospital of the RWTH Aachen. We will analyse serially collected serum from 10 dialysis patients, after ingestion of a single vitamin K supplement, compared to healthy controls. Lipoprotein fractions will be isolated and the corresponding vitamin K contents will be measured by chromatography. The vitamin K supplement contains 3 subforms of vitamin K: vitamin K1 (1000µg), menaquinone-4 (1000µg) and menaquinone-7 (200µg).

Conditions

• Vitamin K Deficiency

Interventions

Type	Name	Description
DRUG	Vitamin K supplement	Single dose of vitamin K supplement

Timeline

• Start date: 2020-03-31
• Primary completion: 2021-07-15
• Completion: 2021-09-15
• First posted: 2022-05-04
• Last updated: 2022-05-04

Locations

1 site across 1 country: Germany