NCT05359094

Probiotic Supplements in Chronic Kidney Disease

To Explore the Effect of Probiotic Supplements in Chronic Kidney Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Taichung Veterans General Hospital · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

This research will investigate the effect of oral probiotic supplements on renal function, uremic toxins inflammatory response, nutrition status, gastrointestinal symptoms, and QoL with Chronic kidney disease.

Detailed description

Chronic kidney disease (CKD) with gut microbiota was different from a normal person. Some gut microbiota produces short-chain fatty acids or induces functional enzymes beneficial to patients. On the other hand, some gut microbiota may also metabolize amino acids into p-cresol and indole which were leading to the accumulation of urinary toxins and damage to the kidney. This research will investigate the effect of oral probiotic supplements on renal function, uremic toxins, inflammatory response, nutrition status, gastrointestinal symptoms, and QoL with CKD.

Conditions

• Chronic Kidney Disease

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Placebo	Placebo (Microcrystalline α-cellulose) supplement with a Plant-Dominant Low-Protein Diet
DIETARY_SUPPLEMENT	Probiotics	Probiotics(Pediococcus acidilactici GKA4) supplement with a Plant-Dominant Low-Protein Diet

Timeline

• Start date: 2022-06-01
• Primary completion: 2023-08-08
• Completion: 2024-07-15
• First posted: 2022-05-03
• Last updated: 2024-07-23

Locations

1 site across 1 country: Taiwan