NCT05358899

Accelerated cTBS on Metabolic Dysfunction in People With Schizophrenia

The Effect and Safety of Accelerated Continuous Theta-burst Stimulation on Metabolic Dysfunction in People With Schizophrenia

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Central South University · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

cTBS is a promising novel intervention, which has strong potential on moderating disease syndrome. However, the most effective pattern of the cTBS is still under debate. Therefore, the investigators designed this randomized controlled clinical trial to evaluate the efficacy and safety of accelerated cTBS, with 1800 stimulation per session, on intervention to metabolic side effects in individuals with schizophrenia.

Conditions

• Schizophrenia
• Metabolic Disturbance
• Eating Behavior
• Transcranial Magnetic Stimulation

Interventions

Type	Name	Description
DEVICE	accelerated theta burst stimulation	cTBS was administered at 80% of each participant's M1 area in a burst-firing pattern (3 pulses at 50 Hz) with a repetition frequency of 5 Hz (200 ms intervals). During each session, participants received 1800 pulses (120 s).
DEVICE	Sham stimulation	Similar process with the accelerated theta burst stimulation with the coil 90 degrees tilted to the surface of the scalp, which could produce identical sound and vibration while avoiding real magnetic stimulation.

Timeline

• Start date: 2022-06-01
• Primary completion: 2022-12-01
• Completion: 2023-05-01
• First posted: 2022-05-03
• Last updated: 2022-11-21

Locations

1 site across 1 country: China