NCT05358626

Seroprevalence of Infection-induced SARS-CoV-2 Antibodies (COVID-19) in Children

Seroprevalence of Infection-induced IgG Antibodies to SARS-CoV-2 in Children Seeking Medical Care in Vietnam

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 4,032 (actual)
• Sponsor: National Children's Hospital, Vietnam · Academic / Other
• Sex: All
• Age: 0 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

It is unknown what proportion of children have been exposed to SARS-CoV-2 and how many have antibodies among children seeking medical care for non-Covid-19 related conditions. The aim of this study is to identify children with IgG antibodies to SARS-CoV-2 who have not been previously diagnosed and are presumed/confirmed Covid-19 negative, then determine the level of immunity in this population which could inform further decisions about covid-19 vaccine strategies for children

Detailed description

Enrolled participants will have a survey about demographic information, history of previous suspected/confirmed Covid-19 infection or exposed to SARS-CoV-2, Covid-19 vaccination status. For participants aged less than 12 months, participants' mothers' status of Covid-19 vaccination and/or previous infection will be recorded. Participants will then complete serologic testing for SARS-CoV-2 IgG antibodies using residual plasma specimens collected/stored for routine laboratory tests on the date of enrollment. The study will characterize the prevalence of antibody positivity in this population and assess whether there is a correlation between demographic characteristics and antibodies levels.

Conditions

• COVID-19

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	SARS-CoV-2 IgG Antibody testing	IgG Antibody testing for previous exposure to SARS-CoV-2

Timeline

• Start date: 2022-03-13
• Primary completion: 2022-06-05
• Completion: 2022-11-13
• First posted: 2022-05-03
• Last updated: 2023-03-09

Locations

1 site across 1 country: Vietnam