NCT05357638

Physical Training for People With Parkinson's Disease and Multiple Sclerosis: Effect on Mind and Body

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 48 (estimated)
• Sponsor: Amsterdam UMC, location VUmc · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

People with Parkinson's disease and Multiple Sclerosis experience disabling motor and non-motor symptoms, which respond insufficiently to medication. To adequately alleviate disease burden, physical training is increasing acknowledged as an assisting therapy; however, the optimal dose of exercise in unknown.

Detailed description

Next to complex motor deficits, people with Parkinson's disease and Multiple Sclerosis experience highly disabling non-motor symptoms; for example, anxiety and depression, cognitive decline, fatigue, and sleep problems. Physical training is increasingly recognized as an assisting and, importantly, safe therapy for these patients to alleviate disease burden. However, the optimal dose (i.e., type, frequency, intensity, duration) of exercise has not yet been established. This study aims to investigate differences in response patterns of motor and non-motor symptoms, blood-based biomarkers of neuroplasticity and neurodegeneration, as well as functional brain connectivity to eight weeks of high intensity interval training \[2x/week, \~30 min/session\], continuous aerobic training \[2x/week, \~50 min/session\], or movement advice \[+3000 steps/day for 5 days/week monitored with an activity tracker\]. Frequently repeated assessment of outcomes measures will be conducted.

Conditions

• Parkinson Disease
• Multiple Sclerosis

Interventions

Type	Name	Description
BEHAVIORAL	High Intensity Interval Training (HIIT)	8 weeks of HIIT, 2x/week for about 30 minutes/session on a cycle ergometer
BEHAVIORAL	Continuous Aerobic Training (CAT)	8 weeks of CAT, 2x/week for about 50 minutes/session on a cycle ergometer
BEHAVIORAL	Movement Advice	Weekly step goal, monitored using an activity tracker, +3000 steps/day for 5 days/week, step goal is based on average step count in the 4 weeks of baseline prior to the intervention

Timeline

• Start date: 2022-05-02
• Primary completion: 2025-05-02
• Completion: 2025-11-02
• First posted: 2022-05-03
• Last updated: 2023-04-25

Locations

1 site across 1 country: Netherlands