NCT05357443

SH Dr. Chen Gastric Bypass Study

Effect of Vagus Nerve Preservation During Gastric Bypass on Gastrin Level and Marginal Ulcer Formation

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Sanford Health · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Evaluation of serum gastrin levels and their effect on marginal ulcer formation.

Detailed description

Prospective, randomized, interventional trial. Participants will be randomized to one of two surgical techniques, either with transection of the vagal nerves, or without. Outcomes including compare marginal ulcer rates will be compared using serum gastrin levels before and after surgery and gastric pH during surgery.

Conditions

• Gastric Bypass

Interventions

Type	Name	Description
PROCEDURE	Gastric bypass with transection of vagal nerves	Vagal nerve interruption above the level of the stomach is a known treatment for complicated peptic ulcer disease. It is not commonly performed during routine gastric bypass. The vagi are, however, interrupted part-way down the stomach to create the gastric pouch. This is the pars flaccida technique.
PROCEDURE	Gastric bypass without transection of vagal nerves	Dissection between the neurovascular bundle and the stomach, spareing the vagus nerves. This is the perigastric technique.

Timeline

• Start date: 2022-08-31
• Primary completion: 2026-09-01
• Completion: 2027-09-01
• First posted: 2022-05-02
• Last updated: 2025-09-30

Locations

1 site across 1 country: United States