NCT05356286

Recording of Intraoperative Spinal Cord Stimulation and Monitoring

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: University of California, Los Angeles · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Opioid overdose suppresses brainstem respiratory circuits, causes apnea, and may result in death. Epidural electrical stimulation (EES) at the cervical spinal cord facilitated motor activity in rodents and humans, and we hypothesized that EES of the cervical spinal cord could antagonize opioid-induced respiratory depression in humans. In this study, we will stimulate the spinal cord during surgery and assess its effects on respiratory function in human patients.

Conditions

• Cervical Stenosis
• Disk, Herniated
• Spondylosis

Interventions

Type	Name	Description
DEVICE	epidural electrical stimulation	Electrical spinal cord stimulation will be used to modulate respiratory function during general anesthesia.

Timeline

• Start date: 2011-01-21
• Primary completion: 2027-01-22
• Completion: 2027-01-22
• First posted: 2022-05-02
• Last updated: 2025-03-10

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study