NCT05354635

Therapeutic Follow-up of Antibiotics in Pediatric Intensive Care

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 280 (estimated)
• Sponsor: Centre Hospitalier Universitaire de la Réunion · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Currently, recommendations for antibiotic testing (ATS) in adult intensive care have been published. The 2018 SFAR and the Abdul- Aziz et al expert conference recommend routine testing for β-lactams, aminoglycosides, linezolid, and vancomycin and provide plasma concentration goals. No recommendations have been made for the pediatric intensive care unit (PICU) population. However, several articles report suboptimal plasma concentrations for the most frequently used antibiotics in PICU. The University Hospital of Reunion is the reference center for the western region of the Indian Ocean. This region presents a large mixed population due to the migratory flow, as well as a specific bacterial ecology. This suggests that the data already collected on antibiotic dosage in other European studies may not be fully extrapolated to Reunion Island. It is in this context that we will study the plasma concentration of antibiotics for all children who received the most commonly used antibiotics (β-lactams, linezolid, vancomycin, and aminoglycosides) during their hospitalization in PICU.

Conditions

• Intensive Care Units, Pediatric

Interventions

Type	Name	Description
OTHER	Antibiotics Dosing	Dosing concerns the main antibiotics used in the unit: b-lactams, linezolid, vancomycin and aminosides

Timeline

• Start date: 2022-06-01
• Primary completion: 2025-06-01
• Completion: 2025-06-01
• First posted: 2022-04-29
• Last updated: 2022-04-29

Locations

1 site across 1 country: Reunion