NCT05354206

Neural Facilitation of Movements in People With SCI

Neural Facilitation of Stimulation-assisted Movements in People With Spinal Cord Injury

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: 16 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Spinal cord injury leads to long-lasting paralysis and impairment. Re-enabling movement of paralyzed areas is challenging and more information is needed about neurological recovery. The purpose of this study is to understand the contribution of individual neural tracts to movements facilitated by transcutaneous spinal cord stimulation (SCS).

Detailed description

Spinal cord injury leads to long-lasting motor impairment and paralysis that currently is not "curable". Electrical spinal cord stimulation (SCS) is beginning to be used as a neuromodulation technique to re-enable movement of paralyzed areas, however the mechanisms of neurorecovery induced by electrical neuromodulation of the spinal cord remain poorly understood. The goal of this project is to generate evidence-based knowledge of changes in the short-term excitability of corticospinal and reticulospinal neural structures that may mediate immediate improvements in motor function enabled by SCS. The proposed study will: (1) determine which kinds of SCS-facilitated movements are mediated by the corticospinal tract. (2) determine which kinds of SCS-facilitated movements are mediated by the reticulospinal tract. Having a better understanding of the neural mechanisms that are enhanced by SCS can allow the development of therapies that directly target the excitability and plasticity states of these structures towards improved and accelerated recovery.

Conditions

• Spinal Cord Injuries

Interventions

Type	Name	Description
OTHER	Electrophysiology assessment - corticospinal tract	Kinematics and cortical spinal motor excitability
OTHER	Electrophysiology assessment - reticulospinal tract	Kinematics and reticular spinal motor excitability
OTHER	Training with some stimulation	Motor task combined with real or sham stimulation

Timeline

• Start date: 2022-06-23
• Primary completion: 2023-03-06
• Completion: 2023-03-06
• First posted: 2022-04-29
• Last updated: 2024-11-22
• Results posted: 2024-11-22

Locations

1 site across 1 country: United States