Trials / Unknown
UnknownNCT05352685
Effects of Propofol on Auditory Event-related Potentials and Brain Functional Connectivity in Patients With Supratentorial Glioma
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- Sponsor
- Beijing Tiantan Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years – 60 Years
- Healthy volunteers
- Accepted
Summary
The growth of gliomas often infiltrates important brain tissues and impairs subcortical fiber transmission, resulting in changes in global brain network connectivity. Most of the current anesthesia depth monitoring methods are based on healthy brain function population，which is difficult to reflect the sedation depth of glioma patients accurately. Therefore, this study aims to explore the characteristics of brain network connectivity in glioma patients under different sedation depths by electroencephalogram (EEG) and auditory event-related potential (AERP) methods, which may provide a research basis for sedative titration and anesthesia depth identification in glioma patients.
Conditions
- Propofol
- Glioma
- Auditory Event-related Potential (AERP)
- Electroencephalogram (EEG)
- Brain Network Connectivity
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Propofol Injection | 1% propofol is used for target-controlled infusion, and gradually increase the effect concentration at 0.2ug/ml. Make the subject's sedation depth reach light sedation and deep sedation respectively. EEG data were collected during wakefulness, light sedation, deep sedation, and recovery. |
Timeline
- Start date
- 2022-05-18
- Primary completion
- 2024-09-30
- Completion
- 2024-09-30
- First posted
- 2022-04-29
- Last updated
- 2023-11-01
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT05352685. Inclusion in this directory is not an endorsement.