NCT05352373

The Role of Dietary Calcium for the Treatment of Osteopenia in Girls With Rett Syndrome

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: Baylor College of Medicine · Academic / Other
• Sex: Female
• Age: 5 Years – 30 Years
• Healthy volunteers: Not accepted

Summary

Randomized, placebo-controlled trial of oral calcium supplementation for osteopenia in girls and women with Rett syndrome

Detailed description

Objective: The investigators conducted a randomized, double-blind, placebo-controlled trial to determine the safety and efficacy of oral calcium supplementation for the treatment of bone mineral deficits in individuals with Rett syndrome (RTT). Methods: The investigators measured total body bone mineral content (BMC) and bone mineral density (BMD) by dual-energy x-ray absorptiometry and biomarkers of bone turnover by clinical laboratory techniques before and one year after oral calcium or placebo supplementation in 32 pre- and post-pubertal girls and young women with RTT. The calcium supplement was calculated to provide a twofold increase in the recommended dietary allowance of calcium for age.

Conditions

• Rett Syndrome

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	calcium	calcium carbonate
DIETARY_SUPPLEMENT	placebo	sodium bicarbonate

Timeline

• Start date: 2008-03-01
• Primary completion: 2012-03-01
• Completion: 2012-03-01
• First posted: 2022-04-28
• Last updated: 2022-04-28