NCT05351749

Implementing Prescriber-Pharmacist Collaborative Care for Evidence-based Anticoagulant Use

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 306 (actual)
• Sponsor: University of Michigan · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The researchers hypothesize that existing-prescription notifications directed to pharmacists are more likely to lead to a prescription change than existing-prescription notifications directed to prescribers. Furthermore, the researchers hypothesize that the availability of a pharmacist referral option is associated with a higher rate of prescription changes for initial-prescription alerts that are directed to the prescriber at the time of initial-prescribing errors. Findings from this project will establish a framework for implementing prescriber-pharmacist collaboration for high risk medications, including anticoagulants

Detailed description

Please note that the 3rd and 4th outcome measures are conditional on the outcomes of the 1st and 2nd outcome measures respectively. Please note that enrollment of 300 will provide sufficient power to study. Study data was obtained through data downloads and not from individual participant interactions. Final data collection for all outcomes took place on Dec 15, 2024.

Conditions

• Pulmonary Embolism
• Venous Thromboembolism
• Atrial Fibrillation

Interventions

Type	Name	Description
BEHAVIORAL	New-prescription Alert	An enhanced drug alert notification in the Michigan Medicine electronic health record (EHR) that is tailored to the specific type of inappropriate Direct Oral Anticoagulant (DOAC) use (e.g., dosing too high for renal dysfunction) and offers decision support to the prescriber to alter a newly prescribed DOAC prescription.
BEHAVIORAL	New-prescription Alert with referral option	An enhanced drug alert notification in the EHR that is tailored to the specific type of inappropriate DOAC use (e.g., dosing too high for renal dysfunction) and offers decision support to the prescriber to alter new DOAC prescription. This alert will ALSO include an option for referral to the anticoagulation clinic pharmacist for assistance.
BEHAVIORAL	Existing-prescription notification to prescriber	Prescriber receives a notification through the EHR indicating an existing DOAC prescription may not be appropriate (e.g. due to renal function change, new drug-drug interactions), and recommending a prescription update.
BEHAVIORAL	Existing-prescription notification to pharmacist	Pharmacist receives a notification through the EHR indicating an existing DOAC prescription may not be appropriate (e.g. due to renal function change, new drug-drug interactions), and recommending a prescription update.

Timeline

• Start date: 2022-08-01
• Primary completion: 2024-12-15
• Completion: 2024-12-15
• First posted: 2022-04-28
• Last updated: 2026-03-30
• Results posted: 2026-03-30

Locations

1 site across 1 country: United States