NCT05351385

S Protein and COVID-19: a Monocentric Prospective Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 70 (estimated)
• Sponsor: University of Milano Bicocca · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to compare plasma S Protein levels to SARS-CoV-2 viral load in COVID positive patients.

Detailed description

Non-pharmacological, non-interventional, prospective, monocentric study involving the use of biological materials. There will be two cohorts: * COVID + cohort: 50 patients with positive nasopharyngeal swab and / or BAL. * Control Cohort: 20 patients with non-SARS-CoV-2 related pneumonia. The study involves analyzing biological samples collected for normal clinical practice. In particular: * blood samples will be used for PROS and Sflt1 assay, haematological, biochemical and coagulation tests. * Samples deriving from nasopharyngeal swab or from Broncho-Alveolar Lavage (BAL) liquid will be used for Real time PCR analysis to evaluate the viral load of SARS CoV-2.

Conditions

• COVID-19

Interventions

Type	Name	Description
PROCEDURE	Hematolgy and Chemistry analysis	Samples will be collected at Day 0, Day 5, Day 10 and Day 15
PROCEDURE	Real Time PCR	Samples will be collected at Day 0, Day 5, Day 10 and Day 15
PROCEDURE	PROS assay COVID+	Samples will be collected at Day 0, Day 5, Day 10 and Day 15
PROCEDURE	Sflt1 assay COVID+	Samples will be collected at Day 0 and Day 10
PROCEDURE	PROS assay CONTROL	Samples will be collected at Day 0 (+5)
PROCEDURE	Sflt1 assay CONTROL	Samples will be collected at Day 0 (+5)

Timeline

• Start date: 2021-09-23
• Primary completion: 2022-06-03
• Completion: 2024-12-03
• First posted: 2022-04-28
• Last updated: 2024-01-02

Locations

1 site across 1 country: Italy