NCT05349903

Impact of Slowly Digestible Carbohydrates on the Gut-brain Axis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Purdue University · Academic / Other
• Sex: All
• Age: 22 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Our laboratory is investigating the physiological outcomes and health benefits of the consumption of high-quality carbohydrates. One important aspect of the high-quality carbohydrate characteristics is a slow and sustained digestion and glucose release to the blood. In the proposed study, the investigators will evaluate the consumption of different types of slowly digestible carbohydrates (SDCs) and their beneficial effects including moderation of the glycemic response profile (postprandial glycemic response, PPGR) and stimulation of the gut-brain axis, which controls appetite and food intake. This stimulation will be evaluated in terms of second-meal food intake and the circulatory level of appetite-suppressing gut hormones (such as glucagon-like peptide-1).

Conditions

• Appetitive Behavior
• Obesity
• Diabetes Mellitus, Type 2

Interventions

Type	Name	Description
OTHER	Rice flour	Rice flour made into rice porridge will be tested for postprandial glycemic response, gut hormone levels, gastric emptying rate, appetitive response, and fermentability.
OTHER	Alternanoligosaccharide 15	Alternanoligosaccharide 15 incorporated into rice porridge will be tested for postprandial glycemic response, gut hormone levels, gastric emptying rate, appetitive response, and fermentability.
OTHER	Inulin	Inulin incorporated into rice porridge will be tested for postprandial glycemic response, gut hormone levels, gastric emptying rate, appetitive response, and fermentability.
OTHER	Waxy potato starch	Retrograded waxy potato starch made into porridge meal will be tested for postprandial glycemic response, gut hormone levels, gastric emptying rate, appetitive response, and fermentability.
OTHER	Waxy potato starch + epigallocatechin gallate (EGCG)	A combination of retrograded waxy potato starch and EGCG made into porridge meal will be tested for postprandial glycemic response, gut hormone levels, gastric emptying rate, appetitive response, and fermentability.
OTHER	Chickpea flour + epigallocatechin gallate (EGCG)	A combination of chickpea flour and EGCG made into porridge meal will be tested for postprandial glycemic response, gut hormone levels, gastric emptying rate, appetitive response, and fermentability.

Timeline

• Start date: 2021-11-10
• Primary completion: 2022-02-24
• Completion: 2022-02-24
• First posted: 2022-04-27
• Last updated: 2022-04-27

Locations

1 site across 1 country: United States