NCT05349864

A Study to Understand the Effect of Low-Fat and High-Fat Meals on the Medicine Called PF-07284890 in Healthy Adults

A PHASE 1, OPEN-LABEL, RANDOMIZED, SINGLE DOSE, 2-SEQUENCE, 3 PERIOD CROSSOVER STUDY TO EVALUATE THE EFFECT OF A LOW-FAT AND HIGH-FAT MEAL ON THE RELATIVE BIOAVAILABILITY OF PF-07284890 IN HEALTHY ADULT PARTICIPANTS

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Pfizer · Industry
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of the study is to evaluate the effect of a low-fat and high-fat meal on the medicine called PF-07284890 following three single doses PF-07284890. The study will include male participants and female participants of non-childbearing potential who are healthy. Participants will be required to stay in the clinical research unit for 15 days and 14 nights.

Conditions

• Healthy Participants

Interventions

Type	Name	Description
DRUG	PF-07284890 Treatment A	PF-07284890 tablet by mouth while fasting
DRUG	PF-07284890 Treatment B	PF-07284890 tablet after low fat meal
DRUG	PF-07284890 Treatment C	PF-07284890 tablet after high fat meal

Timeline

• Start date: 2022-06-17
• Primary completion: 2022-09-16
• Completion: 2022-09-16
• First posted: 2022-04-27
• Last updated: 2024-03-15
• Results posted: 2024-03-15

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study