NCT05349149

IL-6 Regulation of Energy Stores During Recovery From an Acute Exercise Bout

Role of IL-6 in Regulating Energy Stores During Recovery From an Acute Exercise Bout

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Helga Ellingsgaard · Academic / Other
• Sex: Male
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The aim of the study is to investigate the role of exercise-induced IL-6 in regulating energy stores and energy metabolism during recovery after an acute exercise bout. To achieve this, 30 men will be randomized to infusion placebo or tocilizumab (IL-6 receptor antibody) combined with a 2-hour exercise bout. Stable isotope tracers will be infused to determine substrate kinetics. Indirect calorimetry will be applied to determine substrate oxidation, and muscle biopsies will be taken to determine substrate uptake and storage.

Conditions

• Glycogen Depletion

Interventions

Type	Name	Description
DRUG	Tocilizumab/Actemra® (Roche)	The infusion of tocilizumab will antagonize IL-6 signaling for the duration of the study, allowing us to determine the role of IL-6 in regulating energy stores following acute exercise
DRUG	Saline 9%	The infusion of saline will serve as placebo for tocilizumab, allowing us to determine the role of IL-6 in regulating energy stores following acute exercise

Timeline

• Start date: 2022-04-20
• Primary completion: 2022-10-11
• Completion: 2022-10-11
• First posted: 2022-04-27
• Last updated: 2022-10-26

Locations

1 site across 1 country: Denmark