NCT05347667

Menstrual Cycle Phase and Oral Contraceptive Pill (OCP) Use on Muscle Protein Synthesis

Influence of Menstrual Cycle Phase and Oral Contraceptive Pill (OCP) Use on the Muscle Protein Synthetic Response to Exercise in Young, Healthy Women

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: McMaster University · Academic / Other
• Sex: Female
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

Skeletal muscle size and function is regulated by various factors, including hormones. While we understand the role of male sex hormones (testosterone), we aren't sure how female sex hormones (estrogen and progesterone) influence muscle mass and strength. Female physiology is unique in that hormones fluctuate throughout the menstrual cycle. In the first phase (follicular phase) following menstruation, estrogen levels are high while progesterone levels are low. In the second phase (luteal phase), progesterone levels are high. Females are often excluded from studies because researchers are concerned that the menstrual cycle might affect the results. The purpose of this study is to investigate the response to resistance exercise in each phase of the menstrual cycle.

Conditions

• Menstrual Cycle
• Resistance Exercise
• Muscle Protein Synthesis
• OCP

Interventions

Type	Name	Description
OTHER	Unilateral Resistance Exercise Leg	One leg will perform unilateral resistance exercise
OTHER	Control Leg	One leg will serve as a non-exercise control

Timeline

• Start date: 2022-05-01
• Primary completion: 2023-03-01
• Completion: 2024-04-30
• First posted: 2022-04-26
• Last updated: 2025-01-01

Locations

1 site across 1 country: Canada