NCT05331690

Cataract Surgery and Inflammation - the Role for Preoperative NSAIDs (Pre-CIN)

A Randomized Clinical Three-arm Trial Comparing Inflammation and Cystoid Macular Edema for the Medication Regimens Preoperative and Postoperative Topical NSAIDs to Only Postoperative Topical NSAIDs to Postoperative Topical NSAIDs and Steroids in Patients Undergoing Cataract Surgery (Pre-CIN).

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 500 (estimated)
• Sponsor: Oslo University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The pre-CIN trial is a randomized clinical three-arm trial comparing inflammation and cystoid macular edema for the medication regimens preoperative and postoperative topical NSAIDs to only postoperative topical NSAIDs to postoperative topical NSAIDs and steroids in patients undergoing cataract surgery.

Conditions

• Cataract Surgery

Interventions

Type	Name	Description
DRUG	Nepafenac Ophthalmic	Topical nepafenac (Nevanac) 3 mg/ml starter the day before surgery
DRUG	Nepafenac Ophthalmic	Topical nepafenac (Nevanac) 3 mg/ml started the day after surgery
DRUG	Dexamethasone Ophthalmic	Topical dexamethasone 1 mg/ml (Spersadex) started the day after surgery

Timeline

• Start date: 2022-11-25
• Primary completion: 2023-08-01
• Completion: 2023-12-01
• First posted: 2022-04-18
• Last updated: 2022-12-01

Locations

1 site across 1 country: Norway