NCT05328713

Immune Correlates of Cardiac Structure and Function

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 40 (actual)
• Sponsor: Duke University · Academic / Other
• Sex: All
• Age: 20 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the occurrence of scarring of the heart (cardiac fibrosis) and inflammation in those with perinatally acquired Human Immunodeficiency Virus (HIV) infection compared to people not infected with HIV. The information learned from this research may help the investigator to better understand the link between cardiac fibrosis and cardiac dysfunction and inflammation in those with perinatally acquired HIV infection compared to the uninfected. Participants will have a blood sample, complete a patient questionnaire, and have a Magnetic resonance imaging (MRI) and ultrasound of the heart. Researchers will review the medical record and past medical history, for information about your heart function and overall health. Research samples and data from this study will be stored indefinitely and used for other research. There are risks to participate in this study and those risks include side effects from the contrast agent used for the MRI scan, (such as headache and injection site pain), and risks from blood sampling.

Conditions

• Perinatal HIV Infection
• Cardiac Fibrosis
• Cardiac Inflammation

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Cardiac MRI	This study will use Cardiac MRI to identify subclinical cardiac dysfunction.

Timeline

• Start date: 2022-05-09
• Primary completion: 2022-09-21
• Completion: 2022-09-21
• First posted: 2022-04-14
• Last updated: 2024-03-21

Locations

1 site across 1 country: United States