NCT05325736

Improvement in Glycemic Response After Bariatric Surgery

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 120 (estimated)
• Sponsor: Weizmann Institute of Science · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

decipher the role of microbiota in glycemic response change after bariatric surgery

Detailed description

Despite the vast knowledge linking the gut microbiome to metabolism and the glucose response, the relation still remains unclear. hopefully, a deep understanding of the mechanisms underlying metabolic improvement following bariatric surgery will make it possible to identify targets for pharmacological intervention, which will reduce the need for surgery and its risks. Previous studies have characterized the microbiome after bariatric surgery, but most suffer from methodological limitations. The current study has the potential to be innovative and make a significant contribution to understanding the mechanisms involved in early metabolic improvement after bariatric surgery.

Conditions

• Bariatric Surgery

Interventions

Type	Name	Description
PROCEDURE	sleeve gastrectomy surgery	participants undergoing sleeve gastrectomy surgery
PROCEDURE	gastric bypass surgery	participants undergoing gastric bypass surgery
PROCEDURE	control	cholecystectomy
PROCEDURE	Pancreatectomy	Collecting a sample of an unidentified healthy pancreas to extract insulin-secreting beta cells from the sample

Timeline

• Start date: 2021-07-01
• Primary completion: 2026-07-01
• Completion: 2026-07-01
• First posted: 2022-04-13
• Last updated: 2025-03-26

Locations

2 sites across 1 country: Israel