NCT05321511

Comparison of Triggers in Double Ovarian Stimulation (DuoStim).

Double Ovarian Stimulation (DuoStim) Comparison of Triggers: Is There Any Advantage Using 3 Different Methods of Trigger for the Second Egg Collection in Predicted Low Responders?

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 165 (estimated)
• Sponsor: Instituto Bernabeu · Academic / Other
• Sex: Female
• Age: 28 Years – 43 Years
• Healthy volunteers: Accepted

Summary

This study aims to investigate the efficacy of 3 different trigggers used for final maturation in the second ovarian stimulation in double stimulation protocol (aGnRH and hCG-rec vs. aGnRH only vs. hCG-rec only). The main objective is to compare the number of all retrieved oocytes and mature oocytes in patients predicted to be low ovarian responders. This is a controlled randomized clinical study where 165 patients will be recruited.

Conditions

• IVF
• LOW OVARIAN RESPONSE

Interventions

Type	Name	Description
DRUG	Triptorelin acetate (a-GnRH)	Adminsitration of triptoreline acetate 0.2 mg for final oocyte maturation in the second ovarian stimuation inthe Double stimulation protocol.
DRUG	Ovitrelle® (hCG)	Adminsitration of coriogonadotropine alfa 250 mcg for final oocyte maturation in the second ovarian stimuation inthe Double stimulation protocol.
DRUG	Decapeptyl 0.1 mg® (a-GnRH) and Ovitrelle® (hCG) used together	Adminsitration of triptoreline acetate 0.2 mg and coriogonadotropine alfa 250 mcg for final oocyte maturation in the second ovarian stimuation inthe Double stimulation protocol.

Timeline

• Start date: 2022-03-03
• Primary completion: 2022-12-31
• Completion: 2023-03-31
• First posted: 2022-04-11
• Last updated: 2022-04-11

Locations

4 sites across 1 country: Spain