NCT05321225

The Level of Blood Brain Barrier Damage Biomarker in Acute Ischemic Stroke

The Level of Blood Brain Barrier Damage Biomarker Predicting Hemorrhagic Transformation Following Acute Ischemic Stroke

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 1,000 (estimated)
• Sponsor: Ji Xunming,MD,PhD · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Hemorrhagic transformation is a common complication of acute ischemic stroke patients . BBB damage is regarded as a major pathophysiological mechanism of hemorrhagic transformation. So, the investigators hypothesis the level of BBB damage biomarker is predictor of intracranial hemorrhage following ischemic stroke.

Detailed description

Hemorrhagic transformation is a common complication of acute ischemic stroke patients . BBB injury often occurs in the early stage of ischemic stroke, leading brain tissue edema or even hemorrhagic transformation with the development of ischemic injury. The biomarker of BBB damage, such as the level of serum occludin, can reflect the extent of BBB injury. So, the investigators hypothesis the level of BBB damage biomarker is predictor of intracranial hemorrhage following ischemic stroke.

Conditions

• Ischemic Stroke

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	the level of biomarker in bood	Elisa is used to test the level of biomarker in blood.

Timeline

• Start date: 2022-03-10
• Primary completion: 2023-03-10
• Completion: 2025-12-31
• First posted: 2022-04-11
• Last updated: 2022-04-15

Locations

1 site across 1 country: China