NCT05319951

Effect of Different Liquids Intake in Vasovagal Reaction After Whole Blood Donation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 6,250 (actual)
• Sponsor: Guangzhou Blood Center · Other Government
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

we compared the effect of 3 different kinds of liquids (water, Oral Rehydration Salt 3 and white granulated sugar water) intake in Vasovagal Reaction After Whole Blood Donation

Detailed description

Vasovagal reaction is the most common type of blood donation reaction. The main cause of this reaction is the decrease of blood volume. Therefore, fluid supplement before blood donation has been proved to be effective in preventing the vagal reaction after blood donation. It was proved that isotonic (sugar \& salt) drink intake before blood donation had a significant effect on reducing vasovagal reaction. However, in 2002, WHO recommended the new reduced osmolarity rehydration formula with better taste. Oral Rehydration Salt 3 has been produced according to WHO formula with standard ingredient and easy to prepare. In addition, in Guangdong culture, sugar water is regarded as a tonic, more easily accepted. So, the aim of our study was to compare the effects of 500 ml water with Oral Rehydration Salt 3, white granulated sugar and conventional recommended water intake prior to blood donation on blood donation reaction after whole blood donation, in order to understand the effect of different liquid supplement on blood donation reaction and the willingness of blood donation again.

Conditions

• Blood Donation

Interventions

Type	Name	Description
DRUG	Oral Rehydration Salts power (iii)	Dissolve 2 packs of Oral Rehydration Salts Power (iii) (5.125g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.
DIETARY_SUPPLEMENT	water with white granulated sugar	Dissolve 2 packs of Taikoo white granulated sugar (5g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.
DIETARY_SUPPLEMENT	water	Recommend the subjects to drink up 500ml water in 20 minutes prior to donation.

Timeline

• Start date: 2021-01-20
• Primary completion: 2021-11-26
• Completion: 2021-12-31
• First posted: 2022-04-11
• Last updated: 2022-10-03

Locations

1 site across 1 country: China