NCT05317611

Intravenous Versus Intraperitoneal Instillation of Ondansetron for Decreasing Incidence of Nausea and Vomiting After Laparoscopic Gynecological Surgeries.

Intravenous Versus Intraperitoneal Instillation of Ondansetron for Decreasing Incidence of Nausea and Vomiting After Laparoscopic Gynecological Surgeries: A Randomized Controlled Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 63 (actual)
• Sponsor: Zagazig University · Other Government
• Sex: Female
• Age: 21 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Study the effect of intraperitoneal instillation vs intravenous ondansetron on PONV added to intraperitoneal bupivacaine for enhanced recovery and to decrease incidence of PONV after laparoscopic surgeries.

Detailed description

Laparoscopic surgeries have many advantages e.g., decreasing postoperative pain, better cosmetic, rapid recovery, and better recovery but also, it has side effects e.g., pain, postoperative nausea and vomiting. There are many risk factors that cause PONV either patient related factors or anesthesia related factors (opioids, inhalational anesthetics, Nitrous oxide and duration of anesthesia) and surgery related factors (intraabdominal, laparoscopic, postoperative pain). Intraperitoneal instillation of drugs can be used for instillation of LA, opoids, ketamine and antiemetics to provide analgesia and manage side effects of laparoscopic surgery. The mechanism of action of ondansetron is inhibition of presynaptic 5-HT3 receptors that located in the peripheral nervous. Study the effect of intraperitoneal instillation vs intravenous ondansetron on PONV added to intraperitoneal bupivacaine for enhanced recovery and to decrease incidence of PONV after laparoscopic surgeries.

Conditions

• Prevention

Interventions

Type	Name	Description
DRUG	Intraperitoneal instillation of ondansetron and bupivacaine	The aim is to detect the effect of intraperitoneal instillation of ondansetron for prevention of postoperative nausea and vomiting
DRUG	Intravenous ondansetron and intraperitoneal instillation of bupivacaine	The aim is to detect effect of intravenous ondansetron for prevention of postoperative nausea and vomiting
DRUG	Intraperitoneal instillation of bupivacaine	The aim is to detect effect of intraperitoneal instillation of bupivacaine

Timeline

• Start date: 2022-07-01
• Primary completion: 2025-01-15
• Completion: 2025-01-26
• First posted: 2022-04-08
• Last updated: 2025-02-04

Locations

1 site across 1 country: Egypt