NCT05316519

Transcutaneous Auricular Vagus Nerve Stimulation to Enhance Motor Learning

Transcutaneous Auricular Vagus Nerve Stimulation: Mechanisms and Therapeutic Potential

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 4 (actual)
• Sponsor: VA Pittsburgh Healthcare System · Federal
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Vagus nerve stimulation (VNS) activates neural pathways leading to the release of chemicals that promote plasticity and learning. Previous work has shown that the auricular branch of the vagus nerve innervates landmarks on the external ear. Work from the PI's laboratory has shown that electrical current applied to the external ear activates neural pathways implicated in the therapeutic effects of VNS. The broad objective of this project is to better understand physiological mechanisms that are modulated by auricular stimulation and its potential to enhance motor learning.

Conditions

• Neurological Injury
• Motor Disorders
• Paresis

Interventions

Type	Name	Description
OTHER	Transcutaneous Vagus Nerve Stimulation	Visuomotor task training with transcutaneous stimulation targeting landmark that activates biomarker

Timeline

• Start date: 2022-06-01
• Primary completion: 2023-12-31
• Completion: 2023-12-31
• First posted: 2022-04-07
• Last updated: 2024-05-09

Locations

1 site across 1 country: United States