NCT05315531

The Effects of Hydration on Gut Health and Thinking

Investigating the Effects of Increased Water Consumption on Markers of Gut Health, Microbiota, and Executive Function

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 23 (actual)
• Sponsor: University of Illinois at Urbana-Champaign · Academic / Other
• Sex: All
• Age: 19 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The central hypothesis is that improving hydration through increased water consumption will change the relative abundance of mucolytic bacteria found in the stool. Therefore the specific aims are 1) to quantify intervention effects on fecal microbiota relative abundance and plasma lipopolysaccharide binding protein, 2) observe the effects of the intervention on bowel frequency and signs/symptoms of gastrointestinal stress, and 3) to investigate relations between executive function and hydration status.

Detailed description

A single arm 3-week hydration intervention will be employed where participants increase their water consumption to 2 (F) or 2.5(M) liters per day which is approximately 70% of the AI for daily water consumption. Pre-test and follow-up measures of fecal microbiota, urinary hydration status, cognitive function, circulating markers, and dietary intake will be assessed at baseline and at 3-week follow up via laboratory visits.

Conditions

• Dehydration
• Cognitive Change
• Gastrointestinal Microbiota

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Water Intake	Participants will increase plain water consumption to at least 70% of the daily adequate intake for Americans depending on their sex.

Timeline

• Start date: 2021-08-23
• Primary completion: 2022-07-29
• Completion: 2022-07-29
• First posted: 2022-04-07
• Last updated: 2024-01-11

Locations

1 site across 1 country: United States