Trials / Unknown
UnknownNCT05311891
Variants of SARS-CoV-2 Causing COVID-19 in Africa
Variants of SARS-CoV-2 in Central and West Africa: Frequency of Circulating Viruses and Implications for the Management and Control of the Pandemic
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 12,600 (estimated)
- Sponsor
- ANRS, Emerging Infectious Diseases · Other Government
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The main objective of this research is to identify and characterize the different molecular variants of SARS-CoV-2, emerging and / or circulating in several countries of Sub-Saharan Africa (Burkina Faso, Côte d'Ivoire, Gabon, Mali, Chad and Republic of Congo) and determine their role in the evolution of the pandemic.
Detailed description
The main objective of this research is to identify and characterize the different molecular variants of SARS-CoV-2, emerging and / or circulating in several countries of Sub-Saharan Africa (Burkina Faso, Côte d'Ivoire, Gabon, Mali, Chad and Republic of Congo) and determine their role in the evolution of the pandemic. The research will combine retrospective and prospective approaches to determine the evolutionary dynamics of the virus since the start of the pandemic. It is planned to sequence the entire Spike protein gene for 1550 viruses and make 300 entire genomes. This work will be supplemented by antibody seroneutralization and respiratory transcriptomics tests, in order to estimate the immuno-virological response of the COVID-19 disease associated with the identified SARS-CoV-2 variants.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | RT PCR | Characterize the different molecular variants of SARS-CoV-2, determine the escape potential of the new variants from neutralization by monoclonal antibodies and currently available vaccines and characterization of the mRNAs expressed in infected persons |
Timeline
- Start date
- 2022-09-01
- Primary completion
- 2022-10-01
- Completion
- 2022-10-01
- First posted
- 2022-04-05
- Last updated
- 2022-05-27
Locations
6 sites across 6 countries: Burkina Faso, Chad, Côte d’Ivoire, Gabon, Mali, Republic of the Congo
Source: ClinicalTrials.gov record NCT05311891. Inclusion in this directory is not an endorsement.