NCT05310253

Stress & Social Cognition in BPD (part 2)

"Fight-or-flight" Versus "tend-and-befriend" Response to Behavioral and Pharmacological Interventions in Patients with Borderline Personality Disorder (Part II)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 240 (actual)
• Sponsor: Charite University, Berlin, Germany · Academic / Other
• Sex: Female
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The investigators will examine how a combination of pharmacological mineralocorticoid receptor (MR) stimulation and psychosocial stress will influence prosocial behavior in patients with Borderline Personality Disorder (BPD) compared to healthy controls (HC).

Detailed description

The investigators will examine whether MR stimulation enhances prosocial behavior in BPD patients under additional psychosocial stress. Participants will be randomly assigned to receive either fludrocortisone as an MR stimulant or placebo. Afterwards, participants will either undergo the stress or placebo condition of the Trier Social Stress Test ((P-)TSST). Subsequently, cognitive and emotional empathy, as well as sharing and punishment behavior will be measured.

Conditions

• Borderline Personality Disorder

Interventions

Type	Name	Description
DRUG	Fludrocortisone	pill of fludrocortisone
DRUG	Placebo	placebo pill
BEHAVIORAL	Trier Social Stress Test (TSST)	psychosocial stress induction
BEHAVIORAL	Placebo Trier Social Stress Test (P-TSST)	control condition

Timeline

• Start date: 2022-02-01
• Primary completion: 2025-03-01
• Completion: 2025-03-01
• First posted: 2022-04-04
• Last updated: 2025-03-06

Locations

1 site across 1 country: Germany