NCT05308355

Opioid-free Anesthesia and Thoracoscopy Surgery

Evaluation of an "Opioid Free Anesthesia" Protocol in Thoracoscopic Carcinological Thoracic Surgery

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 90 (actual)
• Sponsor: Nantes University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: —

Summary

Evaluation of a service OFA (Opioid-free Anesthesia) protocol on post-operative pain of patients operated on by video-thoracoscopic carcinologic surgery by counting them to a group of patients receiving standard general anesthesia with opioid.

Detailed description

A service protocol based on opioid-free anesthesia in patients undergoing pulmonary carcinologic surgery under video-thoracoscopy will be evaluated. The investigative team want to recruit 100 patients prospectively. These patients will be randomly assigned on the day of surgery between OFA (Opioid Free Anesthesia) and OBA (Opioid Based Anesthesia). Anesthesia and analgesia of patients in the OFA group will be performed without morphine according to the validated local protocol. We will use level 1 and 2 analgesics (paracetamol, NSAIDs and nefopam) associated with an erector spine block and anesthesia under propofol, dexmedetomidine and ketamine ivse. Patients in the OBA group will have so-called "basic" anesthesia and analgesia with opioids according to usual practice. Postoperative pain by collecting morphine consumption in the first 48 hours postoperatively between the two groups will be compared. Chronic neuropathic postoperative pain will also be collected by a telephone questionnaire at 3 months postoperative.

Conditions

• Opioid Free Anesthesia
• Thoracic Surgery

Timeline

• Start date: 2022-04-04
• Primary completion: 2023-04-30
• Completion: 2023-04-30
• First posted: 2022-04-04
• Last updated: 2023-09-13

Locations

1 site across 1 country: France