NCT05307809

Cytokine Expression in Psoriasis Patients with and Without Joint Involvement

Cytokine Expression in Sera, Ex Vivo Stimulated Peripheral Blood Mononuclear Cells Culture, and Skin in Psoriasis - Comparison of Patients with and Without Joint Involvement

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Poitiers University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Accepted

Summary

The objective of the resarch is to study the cytokine profile of patients with psoriatic arthritis and psoriasis in order to better understand the pathophysiology of the disease and the contribution of cytokines to the presence or absence of joint involvement. This research will compare cytokines levels in sera, in PBMC culture after LPS or CD3/CD28 agonist antibodies, and in skin biopsy.

Detailed description

Psoriatic arthritis and Cutaneous Psoriasis are polygenic inflammatory disorders with high burden on the quality of life of patients. Pathophysiology of those disease remain incompletely understood. Recent publications seem to demonstrate an implication of IL-1 family cytokines in the pathogenesis of both diseases. In the literature, results are discordant and focus mainly on cytokines levels in serum of patients. Moreover, few studies compare psoriatic arthritis patients with cutaneous psoriasis patients. We propose here to study cytokines profiles of patients with those conditions in sera, after ex-vivo stimulation of peripheral blood mononuclear cells, and in skin biopsies.

Conditions

• Psoriasis
• Psoriatic Arthritis

Interventions

Type	Name	Description
OTHER	Blood sample collection	Blood sample collection
OTHER	Skin sample collection	Skin sample collection

Timeline

• Start date: 2022-08-17
• Primary completion: 2026-08-17
• Completion: 2026-08-18
• First posted: 2022-04-01
• Last updated: 2024-09-04

Locations

1 site across 1 country: France