NCT05307289

Study of Alterations in Tumor Metabolism Associated With the Development of Immunotherapy Resistance in Melanoma

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Centre Hospitalier Universitaire de Nice · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Among the mechanisms responsible for resistance to immunotherapy, metabolism seems to play a major role. A better understanding of tumor metabolism appears to be absolutely necessary in order to propose efficient therapeutic alternatives to target tumor cells without exerting a deleterious effect on the cells responsible for the anti-tumor immune response. The main objective is to evaluate metabolism modulations in melanoma cells extracted from metastases of patients sensitive and resistant to immunotherapies (anti-PD1 or anti-PD1+anti-CTLA4).

Conditions

• Melanoma (Skin)

Interventions

Type	Name	Description
OTHER	Biposy	Biopsy at inclusion visit and at disease progression if applicable

Timeline

• Start date: 2022-05-25
• Primary completion: 2028-05-25
• Completion: 2028-10-25
• First posted: 2022-04-01
• Last updated: 2025-12-31

Locations

1 site across 1 country: France